Alnylam Pharmaceuticals (NASDAQ:ALNY) vs. G1 Therapeutics (NASDAQ:GTHX) Head-To-Head Review

G1 Therapeutics (NASDAQ:GTHX) and Alnylam Pharmaceuticals (NASDAQ:ALNY) are both medical companies, but which is the superior investment? We will contrast the two companies based on the strength of their risk, earnings, analyst recommendations, dividends, valuation, profitability and institutional ownership.

Insider & Institutional Ownership

73.4% of G1 Therapeutics shares are owned by institutional investors. Comparatively, 89.8% of Alnylam Pharmaceuticals shares are owned by institutional investors. 14.5% of G1 Therapeutics shares are owned by insiders. Comparatively, 3.6% of Alnylam Pharmaceuticals shares are owned by insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a company is poised for long-term growth.

Profitability

This table compares G1 Therapeutics and Alnylam Pharmaceuticals’ net margins, return on equity and return on assets.

Net Margins Return on Equity Return on Assets
G1 Therapeutics N/A -28.35% -27.19%
Alnylam Pharmaceuticals -929.51% -55.33% -46.66%

Analyst Recommendations

This is a breakdown of current recommendations for G1 Therapeutics and Alnylam Pharmaceuticals, as reported by MarketBeat.

Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
G1 Therapeutics 0 1 6 1 3.00
Alnylam Pharmaceuticals 1 4 13 0 2.67

G1 Therapeutics presently has a consensus price target of $66.00, indicating a potential upside of 116.68%. Alnylam Pharmaceuticals has a consensus price target of $127.44, indicating a potential upside of 76.98%. Given G1 Therapeutics’ stronger consensus rating and higher probable upside, analysts plainly believe G1 Therapeutics is more favorable than Alnylam Pharmaceuticals.

Risk & Volatility

G1 Therapeutics has a beta of 2.68, meaning that its stock price is 168% more volatile than the S&P 500. Comparatively, Alnylam Pharmaceuticals has a beta of 2.5, meaning that its stock price is 150% more volatile than the S&P 500.

Earnings & Valuation

This table compares G1 Therapeutics and Alnylam Pharmaceuticals’ revenue, earnings per share and valuation.

Gross Revenue Price/Sales Ratio Net Income Earnings Per Share Price/Earnings Ratio
G1 Therapeutics N/A N/A -$85.29 million ($2.56) -11.90
Alnylam Pharmaceuticals $74.91 million 102.41 -$761.49 million ($7.57) -9.51

G1 Therapeutics has higher earnings, but lower revenue than Alnylam Pharmaceuticals. G1 Therapeutics is trading at a lower price-to-earnings ratio than Alnylam Pharmaceuticals, indicating that it is currently the more affordable of the two stocks.

Summary

G1 Therapeutics beats Alnylam Pharmaceuticals on 10 of the 14 factors compared between the two stocks.

About G1 Therapeutics

G1 Therapeutics, Inc., a clinical-stage biopharmaceutical company, engages in the discovery, development, and commercialization of novel small molecule therapeutics for the treatment of patients with cancer. It is developing trilaciclib, an intravenous cyclin-dependent kinases (CDK) 4/6 inhibitor that is in Phase Ib/II clinical trials for patients with extensive-stage small cell lung cancer, as well as Phase II clinical trial for patients with first-/second-/third-line metastatic triple-negative breast cancer; lerociclib, an oral CDK4/6 inhibitor that is in Phase Ib/IIa clinical trials for the treatment of breast cancer and in Phase Ib/II clinical trial for non-small cell lung cancer; and G1T48, an oral selective estrogen receptor degrader, which is in Phase I clinical trial. The company was founded in 2008 and is headquartered in Research Triangle Park, North Carolina.

About Alnylam Pharmaceuticals

Alnylam Pharmaceuticals, Inc., a biopharmaceutical company, focuses on discovering, developing, and commercializing RNA interference (RNAi) therapeutics. The company's pipeline of investigational RNAi therapeutics focus on genetic medicines, cardio-metabolic diseases, hepatic infectious diseases, and central nervous system/ocular diseases. It provides ONPATTRO (patisiran), a lipid complex injection for the treatment of the polyneuropathy of hereditary transthyretin-mediated amyloidosis in adults. The company's development programs include Vutrisiran, an investigational RNAi therapeutic targeting transthyretin that is in Phase III trials for the treatment of transthyretin-mediated amyloidosis; Givosiran that is in Phase III trials to treat acute hepatic porphyrias; and Lumasiran, an investigational RNAi therapeutic, which is in Phase III clinical trials for glycolate oxidase to treat primary hyperoxaluria type 1. It is also developing Inclisiran, an investigational RNAi therapeutic targeting proprotein convertase subtilisin/kexin type 9 that is in Phase III clinical trials for the treatment of hypercholesterolemia; and Fitusiran, an investigational RNAi therapeutic that is in Phase III clinical trials for treating hemophilia A and B with or without inhibitors. In addition, the company engages in the development of Cemdisiran for complement-mediated diseases; ALN-AAT02 to treat alpha-1 anti-trypsin deficiency-associated liver disease; ALN-HBV02 for treating chronic hepatitis B virus infection; and other earlier-stage programs. Alnylam Pharmaceuticals, Inc. has strategic alliances primarily with Sanofi Genzyme; The Medicines Company; Ionis Pharmaceuticals, Inc.; and Regeneron Pharmaceuticals, Inc. The company was founded in 2002 and is headquartered in Cambridge, Massachusetts.

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