Critical Contrast: Entasis Therapeutics (NASDAQ:ETTX) and NuCana (NASDAQ:NCNA)

Entasis Therapeutics (NASDAQ:ETTX) and NuCana (NASDAQ:NCNA) are both small-cap medical companies, but which is the better investment? We will contrast the two businesses based on the strength of their analyst recommendations, valuation, earnings, profitability, dividends, risk and institutional ownership.

Profitability

This table compares Entasis Therapeutics and NuCana’s net margins, return on equity and return on assets.

Net Margins Return on Equity Return on Assets
Entasis Therapeutics N/A N/A N/A
NuCana N/A -15.27% -14.38%

Analyst Ratings

This is a breakdown of recent ratings and target prices for Entasis Therapeutics and NuCana, as reported by MarketBeat.com.

Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Entasis Therapeutics 0 0 4 0 3.00
NuCana 0 0 3 0 3.00

Entasis Therapeutics currently has a consensus price target of $18.75, suggesting a potential upside of 190.70%. NuCana has a consensus price target of $36.00, suggesting a potential upside of 246.82%. Given NuCana’s higher probable upside, analysts plainly believe NuCana is more favorable than Entasis Therapeutics.

Institutional and Insider Ownership

65.0% of Entasis Therapeutics shares are owned by institutional investors. Comparatively, 38.0% of NuCana shares are owned by institutional investors. 23.1% of Entasis Therapeutics shares are owned by insiders. Strong institutional ownership is an indication that hedge funds, endowments and large money managers believe a company will outperform the market over the long term.

Earnings & Valuation

This table compares Entasis Therapeutics and NuCana’s top-line revenue, earnings per share and valuation.

Gross Revenue Price/Sales Ratio Net Income Earnings Per Share Price/Earnings Ratio
Entasis Therapeutics $5.00 million 16.94 -$32.95 million ($12.31) -0.52
NuCana N/A N/A -$18.47 million ($0.57) -18.21

NuCana has lower revenue, but higher earnings than Entasis Therapeutics. NuCana is trading at a lower price-to-earnings ratio than Entasis Therapeutics, indicating that it is currently the more affordable of the two stocks.

Summary

Entasis Therapeutics beats NuCana on 7 of the 10 factors compared between the two stocks.

About Entasis Therapeutics

Entasis Therapeutics Holdings, Inc. operates as a clinical stage biopharmaceutical company. It focuses on the discovery and development of novel antibacterial products. The firm develops a portfolio of innovative cures for serious drug-resistant bacterial infections. Its anti-infective discovery platform has produced a pipeline of differentiated programs, which is bacterial infections, including ETX2514SUL (targeting Acinetobacter baumannii infections), ETX0282CPDP (targeting Enterobacteriaceae infections), Non-Beta-lactam PBP inhibitor, and Zoliflodacin. Entasis Therapeutics Holdings was founded in March 2018 and is headquartered in Waltham, MA.

About NuCana

NuCana plc, a clinical-stage biopharmaceutical company, engages in the development of products for the treatment of cancer. It is developing Acelarin that is in Phase I clinical trials for the treatment of advanced metastatic solid tumors; Phase Ib clinical trials for the treatment of recurrent ovarian cancer; Phase II clinical trials for the treatment of patients with platinum-resistant ovarian cancer; Phase Ib clinical trials for the treatment of patients with biliary cancer; and Phase III clinical trials for the treatment of pancreatic cancer. The company is also developing NUC-3373, a ProTide transformation of the active anti-cancer metabolite of 5-fluorouracil, which is in Phase I clinical trial for the treatment of patients with advanced solid tumors; and NUC-7738, a nucleoside analog that is in Phase 1 clinical trial for the treatment of patients with advanced solid tumors and hematological tumors. It has a research, collaboration, and license agreement with Cardiff University and University College Cardiff Consultants Ltd. for the design, synthesis, characterization, and evaluation of ProTides; and an assignment, license, and collaboration agreement with Cardiff ProTides Ltd. The company was formerly known as NuCana BioMed Limited and changed its name to NuCana plc in August 2017. NuCana plc was incorporated in 1997 and is headquartered in Edinburgh, the United Kingdom.

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